Deviant lysosomal K+ fluxes and Parkinson’s. A calci-centric point of view
نویسندگان
چکیده
• TMEM175 encodes a lysosomal K + channel gated by AKT in kinase-independent way. A variant which increases risk of Parkinson’s reduces activity. decreases activity but only upon starvation. Knockout mice induces like pathology vivo . deficiency may deregulate Ca 2+ dynamics secondary to changes membrane potential.
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ژورنال
عنوان ژورنال: Cell Calcium
سال: 2021
ISSN: ['1532-1991', '0143-4160']
DOI: https://doi.org/10.1016/j.ceca.2021.102418